Endocrine Abstracts

Introduction: In our country, Sheehan syndrome is one of the most common causes of pituitary insufficiency in female patients.Case: A 54-year-old female patient developed cardiac arrest after an elective hip replacement surgery, and after 5 minutes of cardio pulmonary resuscitation, the rhythm returned to normal and the patient was intubated. Since she was hypotensive, she was given the infusion of noradrenaline after dopamine infusion, but despite this ...

Introduction: Since the thyroid myxedema coma is rarely seen nowadays, its diagnosis can be overlooked.Case: The patient with tracheostomy who underwent total laryngectomy and bilateral neck dissection and radiotherapy (RT) at the neck region 10 years ago due to Larynx cancer was admitted to the intensive care unit the diagnosis periorbital edema, hypotension, hypothermia, consciousness disorder and pneumosepsis. Treatment was started for Acinobacter, wh...

Introduction: Although in-vitro models suggest GH-induced differentiation, migration and survival of astrocytes and oligodendrocytes, no studies had been published in-vivo. We want to evaluate the efficacy and safety of GH associated with physical therapy compared to placebo in patients with complete spine injury (SI) and associated GH deficiency (GHD).Methods: Eighteen Patients with complete SI were screened for GHD (glucagon test). 12 severe (...

Diabetes insipidus (DI) is a disorder that characterized by producing large volume of urine for daily due to the problems at the arginine vasopressin (AVP-NPII), aquaporin 2 (AQP2) and arginine vasopressin receptor 2 (AVPR2) genes. These problems can be inherited or acquired. Among these genes, AVPR2 is a G protein coupled receptor and most of the inherited type of DI are caused by mutations in AVPR2 gene. Mutations can cause improper folding of the receptor protein and this s...

Introduction: Langerhans cell histiocytosis (LHH) is an idiopathic, clonal, pleomorphic, neoplastic disorder characterized by the presence of atypical histiocytic cells which are locally or commonly seen in bone, lung, hypothalamus, liver, lymph nodes, mucocutaneous tissues with damaging them.Case: 58 year-old male patient applied to our clinic due to fatigue. On his physical examination, lymphadenopathy and hepatosplenomegaly were absent. In his history...

Diabetes insipidus (DI) is a rare disorder which is characterized with inability to concentrate urine because of severe liquid-balance impairment. Mutations in AVPR2 gene is one of the causes of DI. AVPR2 is a G protein coupled receptor (GPCR) and its specific agonist is arginine vasopressin (AVP). When AVP binds to the AVPR2, which locates on the basolateral side of collecting duct principal cells of the kidney, it triggers accumulation of cAMP in the cell as a seconder messe...

Changes in arginine vazopression type 2 receptor (AVPR2) gene mostly lead to a rare hereditary polyuric disease, X-linked nephrogenic diabetes insipidus (NDI). The disease is characterized by the production of large amounts of urine and an inability to concentrate urine in response to the antidiuretic hormone vasopressin. In our previous study we have identified a novel 388 bp deletion in the AVPR2 gene in a patient with NDI and in his family. For fu...

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

Introduction and aims: It is known that obesity is associated with retinal microvascular changes. Optical coherence tomography (OCT), a new imaging technique, is used to visualize the choroid. In addition, OCT can also give more beneficial information about systemic and eye diseases. We aim to investigate whether or not obesity may impact on choroid and macula thickness.Material and methods: Forty-four subjects who were apply for obesity in our Endocrino...

Diabetes insipidus is a disorder characterised by severe liquid-imbalance because of the inability to concentrate urine. Inactivating mutations in either arginine vasopressin receptor type 2 (AVPR2) or aquaporin 2 (AQP2) gene can cause congenital Nephrogenic diabetes insipidus (NDI). AVPR2 is a G protein-coupled receptor (GPCR) and is mainly expressed at the basolateral site of the kidneys collecting duct principal cells. Activation of this receptor by vasopressin is responsib...